DETERIORATION OF BIOMATERIALS.
Dra. Mónica F. L. de Mele
The aim of this research project is to study the deterioration of biomaterials in the biological
environment and its effect on the human health. Innovative techniques to eradicate biofilms on biomaterials
and on medical and odontological instruments and devices are being developed and assayed. The specific
objects of this research are the following:
To study the biofilm formation at real time and without invasive treatments.
To evaluate the efficacy of antimicrobial agents on the biofilms.
To investigate the deterioration and degradation of the biomaterials in the biological environment and its
effect on its functionality and aesthetic.
To evaluate the effect of the metal ions, released from biomaterials, on biocompatibility.
Metallic biomaterials such as silver, chromium, copper, magnesium, titanium, nickel and their alloys,
and stainless steel as well as non-metallic materials are used as substrata. Pure strains of
microorganisms and consortia isolated from the infected areas are employed to study the biofilm
development. Cytotoxicity studies with cell lines are also made.
María C. Cortizo, Carolina Diaz
María D. Pereda, Nathalie Arnal
Ana Laura De Virgilio, Claudia Grillo
Florencia Alvarez, Claudia Timberi
publications in the frame of this project (2007 - 2008)
* “Influence of the nano-micro-structure of the surface on bacterial adhesion ”.
C. Diaz, M.C. Cortizo, P.L. Schilardi, S. Gomez de Saravia y M.
Fernández Lorenzo de Mele
Materials Research 10, 5-10 (2007).
* “Magnesium and its alloys as degradable biomaterials.
studies using potentiodynamic and eis electrochemical techniques ”.
W-D. Mueller, M.L. Nascimento, M. Zeddies, M. Córsico, L. Gassa y M.
Fernández Lorenzo de Mele
Materials Research 10(1), 5-10 (2007).
* “Nano/microscale Order Affects Early Stages of Biofilm
Formation on Metal Surfaces ”.
C. Díaz, P.L. Schilardi, R.C. Salvarezza y M. Fernández Lorenzo de Mele
Langmuir 23, 11206-11210 (2007).
* “Relationship between radial diffusion of copper ions
form metal disk and cytotoxicity effects. Comparison with results
obtained using extracts. Analysis of some apparently inconsistent
M.D. Pereda, M. Reigosa y M.F. Lorenzo de Mele
Bioelectrochemistry 72, 94-101 (2008).
* “Influence of the surface sub-micropattern on the adhesion
of pioneer bacteria on metals ”.
C. Díaz, P. Schilardi y M.F.L. de Mele
Artificial Organs 32 (4), 292-298 (2008).
* “Biomaterial interface investigated by electrochemical
impedance spectroscopy Advanced ”.
M. Moisel, M.F.L. de Mele y W.-D. Müller
Engineering Materials 10, B33-B46 (2008).